abstract：:We assessed the potential of different MRI measures to detect and quantify skeletal muscle changes with denervation in two mouse models of denervation/neurogenic atrophy. Acute complete denervation and chronic partial denervation were examined in calf muscles after sciatic nerve axotomy and in transgenic SOD1(G93A) mi...

journal_title：Experimental neurology

authors： Zhang J,Zhang G,Morrison B,Mori S,Sheikh KA

更新日期：2008-08-01 00:00:00

abstract：:Systematic protein expression studies in the brain of exercising and sedentary animals have not been carried out so far and it was therefore decided to determine differences in metabolic protein levels in rat hippocampus of sedentary, voluntary and involuntary exercising rats by a proteomic approach. Aged, male Spragu...

journal_title：Experimental neurology

authors： Kirchner L,Chen WQ,Afjehi-Sadat L,Viidik A,Skalicky M,Höger H,Lubec G

更新日期：2008-07-01 00:00:00

abstract：:Acute exposure of peripheral axons to the free radical Nitric Oxide (NO) may trigger conduction block and, if prolonged, Wallerian degeneration. It was hypothesized that this neurotoxic effect of NO may be due primarily to energy restriction by inhibition of mitochondrial respiration. We compared the neurotoxic effect...

journal_title：Experimental neurology

authors： Alvarez S,Moldovan M,Krarup C

更新日期：2008-07-01 00:00:00

abstract：:It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...

journal_title：Experimental neurology

authors： Sebastianelli L,Ledonne A,Marrone MC,Bernardi G,Mercuri NB

更新日期：2008-07-01 00:00:00

abstract：:Mismatches between tissue perfusion-weighted imaging (PWI; an index of blood flow deficit) and cellular diffusion-weighted imaging (DWI; an index of tissue injury) provide information on potentially salvageable penumbra tissue in focal stroke and can identify "treatable" stroke patients. The present pre-clinical studi...

journal_title：Experimental neurology

authors： Legos JJ,Lenhard SC,Haimbach RE,Schaeffer TR,Bentley RG,McVey MJ,Chandra S,Irving EA,Andrew A Parsons,Barone FC

更新日期：2008-07-01 00:00:00

abstract：:Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasti...

journal_title：Experimental neurology

authors： Adkins DL,Hsu JE,Jones TA

更新日期：2008-07-01 00:00:00

abstract：:Hypobaric hypoxia has been implicated with neural degeneration and memory loss. Though there has been considerable knowledge on the role of the p75(NTR) in triggering apoptosis, the occurrence of a similar mechanism in hypoxic stress still remains to be explored. We, in the present study, have tried to explore the rol...

journal_title：Experimental neurology

authors： Hota SK,Barhwal K,Singh SB,Ilavazhagan G

更新日期：2008-07-01 00:00:00

abstract：:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we repo...

journal_title：Experimental neurology

authors： Nita DA,Cissé Y,Timofeev I

更新日期：2008-06-01 00:00:00

abstract：:Substantial progress has been made towards understanding the molecular basis for limited endogenous central nervous system (CNS) axonal growth after injuries such as spinal cord trauma. Realization of the potential benefit of therapeutic interventions requires methods to assess axonal growth and functional reorganizat...

journal_title：Experimental neurology

authors： Harel NY,Strittmatter SM

更新日期：2008-06-01 00:00:00

abstract：:Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...

journal_title：Experimental neurology

authors： Vogt MA,Chourbaji S,Brandwein C,Dormann C,Sprengel R,Gass P

更新日期：2008-05-01 00:00:00

abstract：:Theoretical and experimental analyses of deep brain stimulation (DBS) in the subthalamic nucleus (STN) show both excitatory and inhibitory effects on the neural elements surrounding the electrode. Given these observations, the mechanism underlying the therapeutic effect of STN DBS on parkinsonian motor signs remains u...

journal_title：Experimental neurology

authors： Hahn PJ,Russo GS,Hashimoto T,Miocinovic S,Xu W,McIntyre CC,Vitek JL

更新日期：2008-05-01 00:00:00

abstract：:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effect...

journal_title：Experimental neurology

authors： Adams MM,Shi L,Linville MC,Forbes ME,Long AB,Bennett C,Newton IG,Carter CS,Sonntag WE,Riddle DR,Brunso-Bechtold JK

更新日期：2008-05-01 00:00:00

abstract：:The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyram...

journal_title：Experimental neurology

authors： Immonen T,Alakuijala A,Hytönen M,Sainio K,Poteryaev D,Saarma M,Pasternack M,Sariola H

更新日期：2008-04-01 00:00:00

abstract：:In human diabetes, degenerative and functional disorders of the central nervous system, including depression, are common findings. Defective dentate gyrus (DG) neurogenesis is associated with affective-related disorders and depression. We previously demonstrated reduced DG neurogenesis in a pharmacological type 1 diab...

journal_title：Experimental neurology

authors： Beauquis J,Saravia F,Coulaud J,Roig P,Dardenne M,Homo-Delarche F,De Nicola A

更新日期：2008-04-01 00:00:00

abstract：:Urotensin-II (U-II) is a cyclic peptide identified recently in many mammalian species including man. U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues. Although this peptide has been reported initially to be a potent vasoconstrictor, increas...

journal_title：Experimental neurology

authors： Chuquet J,Lecrux C,Chatenet D,Leprince J,Chazalviel L,Roussel S,MacKenzie ET,Vaudry H,Touzani O

更新日期：2008-04-01 00:00:00

abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...

journal_title：Experimental neurology

authors： Zhang J,Groff RF 4th,Chen XH,Browne KD,Huang J,Schwartz ED,Meaney DF,Johnson VE,Stein SC,Rojkjaer R,Smith DH

更新日期：2008-04-01 00:00:00

abstract：:Angiotensin II type 1 receptor (AT1R) blocker (ARB) has been reported to modify hypertensive cerebrovascular changes; however, it is not clear whether its protective effects are independent of blood pressure. The aim of this study was to clarify the role of AT1R-mediated signals in cerebral circulation by the chronic ...

journal_title：Experimental neurology

authors： Kumai Y,Ooboshi H,Ago T,Ishikawa E,Takada J,Kamouchi M,Kitazono T,Ibayashi S,Iida M

更新日期：2008-04-01 00:00:00

abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

journal_title：Experimental neurology

authors： Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

更新日期：2008-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of...

journal_title：Experimental neurology

authors： Parameshwaran K,Dhanasekaran M,Suppiramaniam V

更新日期：2008-03-01 00:00:00

abstract：:Human immunodeficiency virus-associated distal-symmetric neuropathy (HIV-DSP) is the most common neurological complication of HIV infection. The pathophysiology of HIV-DSP is poorly understood and no treatment is available for this entity. The dorsal root ganglia (DRG) are the principal sites of neuronal damage and ar...

journal_title：Experimental neurology

authors： Hahn K,Robinson B,Anderson C,Li W,Pardo CA,Morgello S,Simpson D,Nath A

更新日期：2008-03-01 00:00:00

abstract：:The failure of axons to regenerate after spinal cord injury remains one of the greatest challenges facing both medicine and neuroscience, but in the last 20 years there have been tremendous advances in the field of spinal cord injury repair. One of the most important of these has been the identification of inhibitory ...

journal_title：Experimental neurology

authors： Hannila SS,Filbin MT

更新日期：2008-02-01 00:00:00

abstract：:This article reviews stem cell-based strategies for spinal cord injury repair, and practical issues concerning their translation to the clinic. Recent progress in the stem cell field includes clinically compliant culture conditions and directed differentiation of both embryonic stem cells and somatic stem cells. We pr...

journal_title：Experimental neurology

authors： Coutts M,Keirstead HS

更新日期：2008-02-01 00:00:00

abstract：:Animal models treated with agricultural chemicals, such as rotenone, reproduce several degenerative features of human central nervous system (CNS) diseases. Glutamate is the most abundant excitatory amino acid transmitter in the mammalian central nervous system and its transmission is implicated in a variety of brain ...

journal_title：Experimental neurology

authors： Moussa CE,Rusnak M,Hailu A,Sidhu A,Fricke ST

更新日期：2008-01-01 00:00:00

abstract：:No current therapy for Parkinson disease has been shown to slow or reverse the progressive course of the disease. As a departure from traditional treatments, gene therapy approaches provide a new hope for realizing this long-sought goal; but before they can be widely employed for use in patients, they must first be su...

journal_title：Experimental neurology

authors： Lewis TB,Standaert DG

更新日期：2008-01-01 00:00:00

abstract：:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. How...

journal_title：Experimental neurology

authors： Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

更新日期：2008-01-01 00:00:00

abstract：:The clinical outcome of peripheral nerve injuries requiring surgical repair is usually poor and efficient therapies do not exist. Recent work has suggested that low-frequency electrical stimulation of the severed nerve which produces repeated discharges of the parent motoneuron perikarya positively influences axonal r...

journal_title：Experimental neurology

authors： Ahlborn P,Schachner M,Irintchev A

更新日期：2007-11-01 00:00:00

abstract：:Glomerular convergence has been proposed to rely on interactions between like olfactory axons, however topographic targeting is influenced by guidance molecules encountered in the olfactory bulb. Disruption of these cues during development misdirects sensory axons, however little is known about the role of bulb-derive...

journal_title：Experimental neurology

authors： Ardiles Y,de la Puente R,Toledo R,Isgor C,Guthrie K

更新日期：2007-10-01 00:00:00

abstract：:Abuse of stimulant drugs such as methamphetamine (METH) and cocaine has been associated with long-lasting persistent behavioral alterations. Although METH-induced changes in the striatal dopaminergic system might play a role in these effects, the potential underlying neuroanatomical substrate for the chronic cognitive...

journal_title：Experimental neurology

authors： Kuczenski R,Everall IP,Crews L,Adame A,Grant I,Masliah E

更新日期：2007-09-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated phosphoprotein that regulates both oxidative stress and inflammatory processes. OPN is present in the rat substantia nigra (SN) and both protein and mRNA levels are up-regulated following a pro-inflammatory insult produced by lipopolysaccharide. We now report on the effects of lesio...

journal_title：Experimental neurology

authors： Iczkiewicz J,Rose S,Jenner P

更新日期：2007-09-01 00:00:00

abstract：:Transgenic mice whose axons and Schwann cells express fluorescent chromophores enable new imaging techniques and augment concepts in developmental neurobiology. The utility of these tools in the study of traumatic nerve injury depends on employing nerve models that are amenable to microsurgical manipulation and gaugin...

journal_title：Experimental neurology

authors： Magill CK,Tong A,Kawamura D,Hayashi A,Hunter DA,Parsadanian A,Mackinnon SE,Myckatyn TM

更新日期：2007-09-01 00:00:00

abstract：:The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

journal_title：Experimental neurology

authors： Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

更新日期：2007-09-01 00:00:00

abstract：:Penile (cavernous) nerves are readily damaged during radical prostatectomy, invariably causing impotence. Erectile function can return, however this may take months or years and capacity often remains poor. Many studies have attempted to improve penile nerve regeneration but have not explored mechanisms underlying the...

journal_title：Experimental neurology

authors： Nangle MR,Keast JR

更新日期：2007-09-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permane...

journal_title：Experimental neurology

authors： Hill JM,Cuasay K,Abebe DT

更新日期：2007-07-01 00:00:00

abstract：:Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the role for nitrosative stress in functional...

journal_title：Experimental neurology

authors： Vareniuk I,Pavlov IA,Drel VR,Lyzogubov VV,Ilnytska O,Bell SR,Tibrewala J,Groves JT,Obrosova IG

更新日期：2007-06-01 00:00:00

abstract：:Although brain pathways activated by sepsis may respond acutely to endotoxin administration, the long-term central response to sepsis is not known. We prepared male rats for hormonal sampling at the circadian nadir (AM) and peak (PM) after cecal ligation and puncture (CLP) or sham surgery. Diurnal variation of cortico...

journal_title：Experimental neurology

authors： Carlson DE,Chiu WC,Fiedler SM,Hoffman GE

更新日期：2007-06-01 00:00:00

abstract：:Cannabis abuse may precipitate the onset of schizophrenia and a dysfunction of the endocannabinoid system may be involved in the pathology of schizophrenia. Nevertheless, only few studies have addressed the neurobiological consequences of cannabis abuse for the development and course of schizophrenia. We measured the ...

journal_title：Experimental neurology

authors： Rentzsch J,Penzhorn A,Kernbichler K,Plöckl D,Gómez-Carrillo de Castro A,Gallinat J,Jockers-Scherübl MC

更新日期：2007-05-01 00:00:00

abstract：:Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate wh...

journal_title：Experimental neurology

authors： Chen CC,Litvak V,Gilbertson T,Kühn A,Lu CS,Lee ST,Tsai CH,Tisch S,Limousin P,Hariz M,Brown P

更新日期：2007-05-01 00:00:00

abstract：:The subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) paradigm is one of the most widely used in vivo models of Parkinson's disease (PD). However, particularly in the mouse model it has remained difficult to reliably detect behavioural correlates for PD. In the present study we apply a novel murine motor t...

journal_title：Experimental neurology

authors： Liebetanz D,Baier PC,Paulus W,Meuer K,Bähr M,Weishaupt JH

更新日期：2007-05-01 00:00:00

abstract：:Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

journal_title：Experimental neurology

authors： Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

更新日期：2007-04-01 00:00:00

abstract：:Ethanol exposure profoundly affects learning and memory and neural plasticity. Key players underlying these functions are neurotrophins. The present study explored the effects of ethanol on the distribution of neurotrophins in the cerebral cortex of the adult rat. Age- and weight-matched pairs of adult male, Long-Evan...

journal_title：Experimental neurology

authors： Bruns MB,Miller MW

更新日期：2007-04-01 00:00:00